Osteoporosis in Children With ALL

Completed

Conditions studied: Leukemia, Lymphocytic, Acute, L1

In brief

Hypothesis: Pediatric patients with acute lymphoblastic leukemia, treated with chronic glucocorticoids as a part of the leukemia treatment protocol, will have an increased incidence and severity of osteoporosis.

Key facts

Study ID

NCT00330538

Run by

Children's Mercy Hospital Kansas City

People needed

20

Starts

2004-03-01

Expected to finish

2006-10-01

Last updated by the study team

2007-04-06

Who can join

Age: 4 and older, up to 18. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• All pediatric patients with a new diagnosis of ALL between ages 4-18
• Patients who are expected to receive glucocorticoids as part of the leukemia treatment protocol
• Bone density measurements must be performed at the diagnosis visit or maximally within 48 hours after the first dose of glucocorticoids

You may not qualify if…

• Patients under 4 years of age are excluded due to lack of age appropriate standards for bone mineral density
• Glucocorticoid therapy of at least one month or longer within the six months prior to DX
• History of connective tissue or musculoskeletal disorders
• Biphosphonate therapy within the past 6 months
• Acute renal failure
• Serum creatinine equal to or higher than 4.5mg/dl
• Positive serum pregnancy test in adolescent females

Where it is running

• Children's Mercy Hospital — Kansas City, Missouri, United States

Full record on ClinicalTrials.gov

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