Using PET-CT to Target and Validate Low-frequency TMS as Treatment for Tinnitus

Completed · Not applicable · Has a placebo group

Conditions studied: Tinnitus

In brief

One out of every five people experience tinnitus (a buzzing, ringing, or roaring sound in the ear) ranging from mild to severe impairment. To date there is no effective therapy that seems to help the tinnitus sufferer. The purpose of this study is to develop a therapy using a technique called Repetitive Transcranial Magnetic Stimulation (rTMS) to hopefully alleviate or reduce the symptoms of tinnitus. This research is being conducted at the University of Arkansas for Medical Sciences (UAMS). Up to twenty (20) right handed subjects, either males or females, 19-65 years of age, with tinnitus that is severe enough for those persons to seek medical attention will have been seen as patients in the UAMS Hearing and Balance Center, where routine testing includes a physical exam, hearing tests, evaluation of middle ear status, and an MRI scan (a machine that acquires visual images of the brain). A diagnosis of tinnitus will be established after ruling out all other possible causes of the tinnitus.

Key facts

Study ID

NCT00329524

Run by

University of Arkansas

People needed

5

Starts

2006-06-01

Expected to finish

2008-08-01

Last updated by the study team

2015-05-04

Who can join

Age: 19 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• right-handed subjects
• 19-65 years of age
• debilitating unilaterial or bilateral tinnitus
• Experiencing the presence of phantom auditory preception for >6 months
• Tinnitus Handicap Questionnaire score of >30

You may not qualify if…

• significant neurological disease
• acoustic neuromas or glomus tumors
• active Meniere's disease
• profound hearing loss
• non English speaking
• personal or family history of epilepsy
• personal history of head injury, aneurysm, stroke, previous cranial neurosurgery, neurological or psychiatric disorders, metal implants in the head or neck, a pacemaker, pregnancy, migraines,
• medications that lower seizure threshold and are contraindicated
• individuals who have been taking certain medications
• claustrophobia
• patients who do not exhibit significant cortical asymmetries on PET

Where it is running

• University of Arkansas for Medical Sciences — Little Rock, Arkansas, United States

Full record on ClinicalTrials.gov

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