Pennsylvania Adolescent Intervention Research Study (PAIRStudy)

Stopped early · Phase 2

Conditions studied: Depression

In brief

Through the TRIAD Project: Pennsylvania Adolescent Intervention Research Study (PAIRStudy; Project 3a) we aim to test the efficacy of a brief treatment aimed at treating depression and family conflict among a population of adolescents with depression, and thereby reducing the future chance of these adolescents initiating smoking. We will examine Attachment-Based Family Therapy (ABFT) for the treatment of depression in comparison with Enhanced Usual Care for Depression (EUCd). Reduction of depression will be measured by a clinically significant reduction of score on the Hamilton Rating Scale for Depression. Second, we will examine how reduction of family conflict mediates the effect of ABFT on depression. The third aim will be an exploratory look at the potential prevention of the onset of smoking. Specifically, we will examine if reduction of depression and/or reductions in family conflict regardless of treatment type reduces the initiation of smoking or reduces smoking behavior at 52 weeks. These aims will be accomplished by randomizing 240 adolescents to one of two treatment conditions: a) Attachment-Based Family Therapy or b) Enhanced Usual Care for Depression. Patients randomized to the ABFT condition will receive 6-12 weeks of family therapy. Patients enrolled in the EUCd condition will be referred for outpatient psychological services at an agency that fits their geographic and financial needs. Research staff will help patients navigate the referral process. All participating therapists will have carried out the full, manualized treatment with 2-3 pilot cases prior to treating any randomized cases.

Key facts

Study ID

NCT00329199

Run by

Pennsylvania Department of Health

People needed

240

Starts

2006-12-01

Expected to finish

2007-05-01

Last updated by the study team

2007-08-20

Who can join

Age: 12 and older, up to 18. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 12 to 17 years of age
• HAM-D score of > 14
• Meet diagnostic criteria for either Major Depressive Disorder, Dysthymia, or Depression NOS
• Have a parent or guardian willing to participate

You may not qualify if…

• Currently Suicidal
• History of mental retardation or borderline intellectual functioning
• Current psychosis
• Primary caregiver unwilling to participate

Where it is running

• Lehigh Valley Hospital — Allentown, Pennsylvania, United States
• The Children's Hospital of Philadelphia — Philadelphia, Pennsylvania, United States
• The Children's Hospital of Pittsburgh — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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