Study Evaluating the Effects of DVS SR and Paroxetine on the Pharmacokinetics of Desipramine in Healthy Subjects

Completed · Phase 3

Conditions studied: Depression

In brief

The purpose of this study is to evaluate the effects of multiple doses of DVS SR and paroxetine on the pharmacokinetics of a single dose of desipramine in healthy subjects.

Key facts

Study ID

NCT00329147

Run by

Wyeth is now a wholly owned subsidiary of Pfizer

People needed

20

Starts

2006-05-01

Expected to finish

2006-06-01

Last updated by the study team

2007-12-07

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy men and women between 18 to 55 years of age
• Healthy as determined by the investigator on the basis of medical history and physical examination, laboratory test results, vital signs, and 12-lead electrocardiogram (ECG)
• History of being a nonsmoker for at least 1 year Other inclusions apply.

You may not qualify if…

• Presence or history of any disorder or significant cardiovascular, hepatic, renal, gastrointestinal, endocrine, immunologic, dermatologic, hematologic, or neurologic condition, and any severe conditions of the ears, eyes or throat (such as glaucoma or increased intraocular pressure) or psychiatric disease
• Known or suspected alcohol abuse or consumption of more than 2 standard units per day within the past 6 months
• Use of any over-the-counter, prescription, hormonal therapy or investigational medications within 30 days of study day-1 until the end of the study Other exclusions apply.

Where it is running

• Study site — Neptune City, New Jersey, United States

Full record on ClinicalTrials.gov

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