The Use of Tissue Oxygen Monitoring in Critically Injured Patients

Stopped early

Conditions studied: Traumatic Brain Injury, Hemorrhagic Shock, Trauma

In brief

It is anticipated that the use of tissue oxygen monitoring to measure brain tissue oxygen and deltoid muscle oxygen will provide more precise information about focal brain ischemia and systemic hypoperfusion than current techniques and measures such as blood pressure, heart rate and intracranial pressure. Understanding the relationship between tissue oxygen tension collected from the brain and deltoid muscle in critically injured patients could lead to a broader understanding of the important metabolic and cellular events that occur following severe injury and the changes induced by therapeutic interventions. Furthermore, the use of interventions designed to improve tissue hypoxia, as measured by low brain or muscle tissue oxygen, may improve mortality or neurological recovery after systemic trauma or head trauma compared to current approaches that do not involve tissue metabolic monitoring.

Key facts

Study ID

NCT00328341

Run by

University of California, San Francisco

People needed

67

Starts

2006-04-01

Expected to finish

2011-12-01

Last updated by the study team

2013-09-19

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18 years and older
• Intubated and assisted mechanical ventilation
• Traumatic brain injury requiring advanced neuromonitoring
• Abbreviated injury scale 3 or more in torso. abdomen, or extremities

You may not qualify if…

• Age less than 18 years
• Pregnancy

Where it is running

• University of California San Francisco, San Francisco General Hospital — San Francisco, California, United States

Full record on ClinicalTrials.gov

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