The Study of Immune Cell (T Cell) Activity in Patients With Paraneoplastic Neurologic Syndromes

Completed

Conditions studied: Paraneoplastic Syndromes

In brief

The investigators believe that T cells, cells that are a part of the immune system, are what are causing the neurological problems while also attacking tumor cells. This protocol studies the clinical status of patients with paraneoplastic neurological disorder (PND) as well as their blood to understand the relationship between their neurological disease, their cancer, and their immune system.

Key facts

Study ID

NCT00327236

Run by

Rockefeller University

People needed

109

Starts

1995-01-01

Expected to finish

2018-02-01

Last updated by the study team

2019-04-10

Who can join

Age: 1 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Neurological disease which is suspected to be paraneoplastic
• No known active additional malignancy other than non-melanoma skin cancer

You may not qualify if…

• Known central nervous system (CNS) metastasis
• Known active additional malignancy
• No pulmonary disease which limits daily activities
• if leukapheresis: must be 14 or older no known hepatitis B or C, HIV, or syphilis (by history or prior negative tests) no known IV drug users HgB > 8.5 WBC > 3,500 platelets > 100,000 INR < 2
• if large blood draw (1/2 to 1 unit; children 3 ml/kg) in lieu of leukapheresis: no known IV drug users HgB > 10 WBC > 3,500 platelets > 100,000 INR < 2
• if lumbar puncture: platelets > 120,000 INR < 1.2 must be 14 or older

Where it is running

• Rockefeller University Hospital — New York, New York, United States

Full record on ClinicalTrials.gov

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