Hepatic Arterial Infusion With Melphalan Compared With Standard Therapy in Treating Patients With Unresectable Liver Metastases Due to Melanoma

Completed · Phase 3

Conditions studied: Intraocular Melanoma, Melanoma (Skin), Metastatic Cancer

In brief

RATIONALE: Drugs used in chemotherapy, such as melphalan, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving melphalan directly into the arteries around the tumor may kill more tumor cells. It is not yet known whether hepatic arterial infusion with melphalan is more effective than standard therapy in treating liver metastases due to melanoma. PURPOSE: This randomized phase III trial is studying hepatic arterial infusion with melphalan to see how well it works compared to standard therapy in treating patients with unresectable liver metastases due to melanoma.

Key facts

Study ID

NCT00324727

Run by

Delcath Systems Inc.

People needed

93

Starts

2006-02-01

Expected to finish

2012-08-01

Last updated by the study team

2021-06-21

Who can join

Age: 18 and older, up to 120. Sex: any. Healthy volunteers: not accepted.

Where it is running

• John Wayne Cancer Institute at Saint John's Health Center — Santa Monica, California, United States
• Swedish Medical Center — Englewood, Colorado, United States
• H. Lee Moffitt Cancer Center and Research Institute at University of South Florida — Tampa, Florida, United States
• Greenebaum Cancer Center at University of Maryland Medical Center — Baltimore, Maryland, United States
• Warren Grant Magnuson Clinical Center - NCI Clinical Trials Referral Office — Bethesda, Maryland, United States
• Carol G. Simon Cancer Center at Morristown Memorial Hospital — Morristown, New Jersey, United States
• Cancer Center of Albany Medical Center — Albany, New York, United States
• Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical Center — Columbus, Ohio, United States
• Providence Cancer Center at Providence Portland Medical Center — Portland, Oregon, United States
• St. Luke's Cancer Network at St. Luke's Hospital — Bethlehem, Pennsylvania, United States
• UPMC Cancer Centers — Pittsburgh, Pennsylvania, United States
• University of Texas Medical Branch — Galveston, Texas, United States

Full record on ClinicalTrials.gov

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