Combined Modality Therapy for Patients With With HIV and Stage I, Stage II, or Stage III Anal Cancer
Completed · Phase 2
Conditions studied: Anal Cancer
In brief
RATIONALE: Drugs used in chemotherapy, such as cisplatin and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as cetuximab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Radiation therapy uses high-energy x-rays to kill tumor cells. Giving cisplatin, fluorouracil, and cetuximab together with radiation therapy may kill more tumor cells. PURPOSE: This phase II trial is studying how well giving cisplatin, fluorouracil, and cetuximab together with radiation therapy works in treating patients with HIV and stage I, stage II, or stage III anal cancer.
Key facts
- Study ID
- NCT00324415
- Run by
- AIDS Malignancy Consortium
- People needed
- 45
- Starts
- 2006-09-01
- Expected to finish
- 2016-05-01
- Last updated by the study team
- 2025-05-30
Who can join
Age: 18 and older, up to 120. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Rebecca and John Moores UCSD Cancer Center — La Jolla, California, United States
- UCLA Clinical AIDS Research and Education (CARE) Center — Los Angeles, California, United States
- Beth Israel Deaconess Medical Center — Boston, Massachusetts, United States
- Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis — St Louis, Missouri, United States
- Albert Einstein Cancer Center at Albert Einstein College of Medicine — The Bronx, New York, United States
- Joan Karnell Cancer Center at Pennsylvania Hospital — Philadelphia, Pennsylvania, United States
- Benaroya Research Institute at Virginia Mason Medical Center — Seattle, Washington, United States
Full record on ClinicalTrials.gov
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