Molecular Quantification of Insulin mRNA

Completed

Conditions studied: Type 1 Diabetes Mellitus

In brief

The objectives of this study are to: 1. quantitate the level of insulin mRNA in the while cell fraction of whole blood in selected groups of subjects, 2. determine the gene expression of markers of white cell activation in the white cell fraction of whole blood in selected subjects, 3. determine the identity of the white cell responsible for expression of insulin mRNA and 4. determine protein expression of mRNA of insulin/proinsulin and selected genes of white cell activation.

Key facts

Study ID

NCT00324207

Run by

Children's Mercy Hospital Kansas City

People needed

400

Starts

2006-02-01

Expected to finish

2009-01-01

Last updated by the study team

2010-03-05

Who can join

Age: 1 and older, up to 17. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Male or female subjects ages 1 to 17 years of age
• Subjects with evidence of beta cell dysfunction or evidence of beta cell autoimmunity
• Subjects with new onset type 1 diabetes
• Non-diabetic and autoantibody negative siblings of subjects with new onset type 1 diabetes
• Unrelated nondiabetic controls with no family history of type 1 diabetes
• Of sufficient size to donate 10ml of blood

You may not qualify if…

• None if subjects meet above inclusion criteria

Where it is running

• Children's Mercy Hospital — Kansas City, Missouri, United States

Full record on ClinicalTrials.gov

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