Sexually Dimorphic Effects of GHRH in Adult Growth Hormone Testing

Completed · Not applicable

Conditions studied: Growth Hormone Deficiency

In brief

Specific Aim 1 Healthy male and female subjects and growth hormone (GH) deficient subjects display sexually dimorphic GH responses to GHRH administration Specific Aim 2 GH responses to GHRH in both healthy controls and in GH deficient patients correlate with expression and activity of the stimulatory G proteins, G alpha q and G alpha S. G protein levels correlate with gonadal steroid levels. Specific Aim 3 Sexually dimorphic GH responses to GHRH are enhanced in Tanner Stage V compared to Tanner Stage 1 individuals

Key facts

Study ID

NCT00324064

Run by

Children's Mercy Hospital Kansas City

People needed

90

Starts

2007-07-01

Expected to finish

2009-07-01

Last updated by the study team

2010-03-05

Who can join

Age: 5 and older, up to 40. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy subjects
• Males and females, Tanner stage V aged 15-40 years of age with no known endocrine problems
• Males and females, Tanner stage I, aged 5-8 years with no known endocrine problems
• GH subjects - Males and females, Tanner stage V, aged 15-21 years with a history of childhood growth hormone deficiency

You may not qualify if…

• Healthy subjects
• History of GH deficiency or treatment or other known endocrine disorder
• Current height or adult height <5th %
• Female subjects using hormonal methods of birth control
• Female subjects with irregular menstrual cycles
• GH subjects
• Subjects with GH deficiency who have not discontinued GH treatment for at least 2 months

Where it is running

• Children's Mercy Hospital — Kansas City, Missouri, United States

Full record on ClinicalTrials.gov

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