Combination Chemotherapy and Bevacizumab in Treating Patients With Stage IV Colon Cancer That Cannot Be Removed By Surgery
Completed · Phase 2
Conditions studied: Colorectal Cancer
In brief
RATIONALE: Drugs used in chemotherapy, such as fluorouracil, leucovorin, and oxaliplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Bevacizumab may also stop the growth of colon cancer by blocking blood flow to the tumor. Giving combination chemotherapy together with bevacizumab may kill more tumor cells. PURPOSE: This phase II trial is studying how well giving combination chemotherapy together with bevacizumab works in treating patients with stage IV colon cancer that cannot be removed by surgery.
Key facts
- Study ID
- NCT00321828
- Run by
- NSABP Foundation Inc
- People needed
- 90
- Starts
- 2006-03-01
- Expected to finish
- 2012-12-01
- Last updated by the study team
- 2024-03-21
Who can join
Age: 18 and older, up to 120. Sex: any. Healthy volunteers: not accepted.
Where it is running
- City of Hope Comprehensive Cancer Center — Duarte, California, United States
- Kaiser Permanente - Fremont — Fremont, California, United States
- Kaiser Permanente Medical Center - Hayward — Hayward, California, United States
- Scripps Cancer Center - San Diego — La Jolla, California, United States
- Kaiser Permanente Medical Center - Oakland — Oakland, California, United States
- Kaiser Permanente Medical Center - Redwood City — Redwood City, California, United States
- Kaiser Permanente Medical Center - Richmond — Richmond, California, United States
- Kaiser Permanente Medical Center - Roseville — Roseville, California, United States
- South Sacramento Kaiser-Permanente Medical Center — Sacramento, California, United States
- Kaiser Permanente Medical Center - Sacramento — Sacramento, California, United States
- Kaiser Permanente Medical Office -Vandever Medical Office — San Diego, California, United States
- Kaiser Permanente Medical Center - San Francisco Geary Campus — San Francisco, California, United States
- Kaiser Permanente Medical Center - Santa Teresa — San Jose, California, United States
- Kaiser Foundation Hospital - San Rafael — San Rafael, California, United States
- Kaiser Permanente Medical Center - Santa Clara Kiely Campus — Santa Clara, California, United States
- Kaiser Permanente Medical Center - Santa Rosa — Santa Rosa, California, United States
- Kaiser Permanente Medical Center - South San Francisco — South San Francisco, California, United States
- Kaiser Permanente Medical Facility - Stockton — Stockton, California, United States
- Kaiser Permanente Medical Center - Vallejo — Vallejo, California, United States
- Kaiser Permanente Medical Center - Walnut Creek — Walnut Creek, California, United States
- Tunnell Cancer Center at Beebe Medical Center — Lewes, Delaware, United States
- CCOP - Christiana Care Health Services — Newark, Delaware, United States
- Sibley Memorial Hospital — Washington D.C., District of Columbia, United States
- Lakeland Regional Cancer Center at Lakeland Regional Medical Center — Lakeland, Florida, United States
- Arkansas Cancer Research Center at University of Arkansas for Medical Sciences — Little Rock, Arkansas, United States
Full record on ClinicalTrials.gov
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