Intravenous (IV) Lidocaine for Opioid-refractory Pain

Withdrawn before enrolling · Phase 2

Conditions studied: Neoplasms, Pain

In brief

Opioid medicines, like morphine, are the main treatment for severe cancer pain. Unfortunately, some patients suffer severe pain despite high doses of opioids. We hypothesize that intravenous lidocaine can quickly and effectively treat this kind of opioid-refractory pain.

Key facts

Study ID

NCT00321347

Run by

San Diego Hospice & Palliative Care

People needed

0

Starts

2006-05-01

Expected to finish

2009-05-01

Last updated by the study team

2012-06-22

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Advanced cancer patient (prognosis ≤6 mos)
• Age ≥ 18 years old
• Opioid-refractory pain
• Steady state levels of adjunctive pain medications
• Intravenous access
• Has decision-making capacity
• Hemodynamics: 85<SBP<210 mm Hg \& 55<HR<120
• EKG QTc ≤ 440 msec

You may not qualify if…

• Methadone use
• Myoclonus
• Seizure disorder
• History of ventricular arrhythmia
• Allergy to amide local anesthetics
• Evidence of cardiac ischemia by history or EKG
• Currently receiving a parenteral local anesthetic
• Pregnancy

Where it is running

• San Diego Hospice & Palliative Care — San Diego, California, United States

Full record on ClinicalTrials.gov

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