Serotonin Transporter Concentrations in Women With a History of Anorexia Nervosa

Completed

Conditions studied: Eating Disorders, Anorexia Nervosa

In brief

This study will compare the concentrations of serotonin transporter in the brains of women with a history of anorexia nervosa who are currently maintaining a normal weight to those of healthy women of normal weight.

Key facts

Study ID

NCT00320684

Run by

New York State Psychiatric Institute

People needed

20

Starts

2003-07-01

Expected to finish

2009-06-01

Last updated by the study team

2012-07-02

Who can join

Age: 18 and older, up to 45. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• History of anorexia nervosa
• BMI has been greater than 18.5 kg/m² for at least 9 months
• Agrees to use an effective method of contraception
• Off all psychotropic and other types of medications likely to impact the serotonin system for at least 21 days

You may not qualify if…

• Use of any psychotropic medication or other types of medications that are likely to affect the serotonin system within 21 days of study entry
• Current DSM-IV Axis-I diagnosis of any illness other than an eating disorder
• Current AN or history of AN within 9 months prior to study entry
• Presence of any psychiatric symptom that would make participation unsafe
• Significant active physical illnesses, particularly those that may affect the brain or serotonergic system, including the following: blood dyscrasias lymphomas; hypersplenism; endocrinopathies; renal failure or chronic obstructive lung disease; autonomic neuropathies; low hemoglobin; anemia; peripheral vascular disease; and malignancy
• Currently receiving effective medication treatment for an eating disorder
• History of Raynaud's phenomena and/or acrocyanosis
• Significant regular tobacco use (defined as more than 1 pack per week)
• Lacks capacity to consent
• Pregnant
• Breastfeeding
• Any metal implants, pacemaker, metal prostheses, orthodontic appliances, or the presence of shrapnel
• Significant history of claustrophobia that would complicate the completion of MRI
• Current or past radiation exposure in the workplace or as part of a research protocol in the previous year
• Badged for radiation
• Inclusion for Healthy Controls:
• Female age 18-45
• BMI >18.5 kg/m
• Drug and medication free
• Willingness to engage in effective birth controls
• Exclusion for Healthy Controls
• History of any DSM-IV Axis - I diagnosis
• History of Axis II disorder that would be accompanied by impulse control problems or significant suicidal behavior
• Significant active physical illness
• Lacks capacity to consent

Where it is running

• New York State Psychiatric Institute — New York, New York, United States

Full record on ClinicalTrials.gov

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