Effectiveness of Baclofen in the Treatment of People With Bulimia Nervosa or Binge Eating Disorder

Completed · Not applicable

Conditions studied: Eating Disorders, Bulimia Nervosa

In brief

This study will evaluate the effectiveness of the drug baclofen in reducing binge eating and associated food cravings in people with bulimia nervosa or binge eating disorder.

Key facts

Study ID

NCT00320047

Run by

New York State Psychiatric Institute

People needed

10

Starts

2005-04-01

Expected to finish

2007-06-01

Last updated by the study team

2013-08-12

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• For people with BN:
• Meets DSM-IV criteria for BN
• Disease duration is more than 1 year
• Self-induces vomiting
• Weighs between 80 and 120% of ideal weight
• Binge eats on at least 6 days during the 2-week run-in period
• For obese people with BED:
• Meets DSM-IV criteria for BED
• Obese (body mass index [BMI] is greater than 30 kg/m²)
• Binge eats on at least 6 days during the 2-week run-in period

You may not qualify if…

• For all participants:
• Significant medical illness
• Current or lifetime history of schizophrenia, bipolar disorder, or other psychotic disorder as defined by DSM-IV-TR
• Moderate to severe depression as defined by a score greater than 18 on the Hamilton Depression Scales
• Current DSM-IV-TR diagnosis of organic mental disorder, factitious disorder, or malingering
• History of a personality disorder (e.g., schizotypal, borderline, or antisocial) that might interfere with assessment or compliance with the study procedures
• At risk for suicide
• Currently taking medication other than birth control pills or over-the-counter medication
• History of drug or alcohol abuse within 3 months prior to study entry
• Pregnant, planning to become pregnant, or breast feeding
• Known intolerance to baclofen, or related muscle relaxants
• Orthostatic hypotension
• Additional exclusion criteria for people with BN:
• Underweight (BMI less than 18 kg/m²)

Where it is running

• Eating Disorders Clinic, New York State Psychiatric Institute — New York, New York, United States

Full record on ClinicalTrials.gov

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