Virulence Determinants in S Aureus Bacteremia
Completed
Conditions studied: Bacteremia
In brief
The purpose of this study is to investigate why some people develop life-threatening infections caused by the bacteria Staphylococcus aureus, while other people do not. It is possible that the infectious ability of the bacteria can determine whether an infection develops and its severity. The investigators will look at old blood and nasal specimens collected from 1000 adults who had S. aureus infections and who were hospitalized at Duke University Medical Center. Previously collected health information regarding these patients and the specific bacterial traits in the samples will be studied. Eventually this information may be used to help treat and prevent S. aureus infection.
Key facts
- Study ID
- NCT00319826
- Run by
- Duke University
- People needed
- 1354
- Starts
- 2004-03-01
- Expected to finish
- 2013-08-01
- Last updated by the study team
- 2016-04-28
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Adults (>= 18 years) with culture-confirmed Staphylococcus aureus bacteremia (SAB). Patients with SAB transferred to Duke University Medical Center are eligible if speculation and antibiotic susceptibilities are confirmed by the Duke Clinical Microbiology Laboratory.
- Absolute neutrophil count of > 1000 cells/cubic millimeter at the time that the initial positive blood culture is obtained.
- Patient or patient's representative provides signed informed consent allowing study participation.
You may not qualify if…
- Prior enrollment of patient in this investigation (to ensure statistical independence of observations).
- Staphylococcus aureus bacteremia (SAB) that is not confirmed by culture and speciation at the Duke Clinical Microbiology Laboratory.
- Outpatient status.
- Isolation of any pathogen other than S. aureus from bloodstream.
- Inability of patient or patient's representative to provide written informed consent.
Where it is running
- Duke University Medical Center — Durham, North Carolina, United States
Full record on ClinicalTrials.gov
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