Heart and Estrogen-Progestin Replacement Study (HERS)

Completed · Phase 3

Conditions studied: Coronary Heart Disease

In brief

The purpose of the study is to determine whether hormone replacement therapy in post menopausal women with coronary artery disease prevents future heart attacks or death from coronary heart disease.

Key facts

Study ID

NCT00319566

Run by

University of California, San Francisco

People needed

2430

Starts

1992-07-01

Expected to finish

2001-07-01

Last updated by the study team

2006-04-27

Who can join

Age: 55 and older, up to 75. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• <75 y.o.
• uterus present
• postmenopausal
• evidence of CHD
• signed consent

You may not qualify if…

• MI, CABG, mechanical revascularization within 6 months
• serum triglyceride >300mg/dl
• used hormone therapy or estrogen vaginal cream in past 3 months
• history of DVT or pulmonary embolism
• history of breast cancer or mammogram suggestive of cancer
• history of endometrial cancer
• abnormal uterine bleeding
• pap smear abnormal
• SGOT more than 1.2 times normal
• Disease judged to be fatal within 4 yrs
• alcoholism, drug abuse
• NYHA Class IV congestive heart failure
• uncontrolled hypertension
• uncontrolled diabetes
• participation in any other investigational study

Where it is running

• University of California San Francisco — San Francisco, California, United States

Full record on ClinicalTrials.gov

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