Effects of Age and Exercise on Blood Pressure Regulation

Status unconfirmed

Conditions studied: Cardiovascular Disease, Aging

In brief

The purpose of this study is to investigate the effects of age, exercise and cardiovascular disease on blood pressure.

Key facts

Study ID

NCT00319397

Run by

National Institute on Aging (NIA)

People needed

80

Starts

2004-04-01

Expected to finish

2007-03-01

Last updated by the study team

2009-12-14

Who can join

Age: 55 and older, up to 75. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Sedentary Older Individuals Group:
• Healthy men and women ages 55-75
• Normally physically active (performing regular aerobic exercise less than 60 minutes per week) with aerobic capacities below the 80th percentile for age and gender
• Coronary Artery Disease (CAD) Group:
• Men and women ages 55-75
• Written authorization from participant's cardiologist to participate in the study (Note: if Dr. Zervos is the participant's cardiologist, their primary care physician will also be asked to give written authorization)
• Documented CAD by previous MI or angiography

You may not qualify if…

• General exclusion criteria for all groups:
• Neurological diseases
• Diabetes
• History of migraine headaches
• Hypertension
• Glaucoma
• Pacemaker
• History of stroke or TIA
• High cholesterol
• Current cancer
• Benign prostatic hyperplasia
• Allergy to sulfa
• Carotid disease
• Currently taking anti-depression, anti-psychotic, or anti-anxiety medications
• Sedentary Older Individuals Group:
• Coronary artery or carotid vascular disease
• Coronary Artery Disease (CAD) Group:
• Myocardial Infarction (MI), Percutaneous Transluminal Coronary Angioplasty (PTCA) or Coronary Artery Bypass Graft (CABG) in the last 3 months
• Unstable angina, EF branch block severe valvular disease, chronic atrial fibrillation, and frequent atrial or ventricular arrhythmias (including more than 3 PVCs or APCs per minute)
• Currently taking anticoagulants or any cardioactive medications other than ACE inhibitors, calcium channel blockers, and beta-blockers

Where it is running

• Spaulding Rehabilitation Hospital — Boston, Massachusetts, United States (enrolling)

Full record on ClinicalTrials.gov

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