Treatment of Ragweed-Allergic Asthma With an Immunostimulatory Drug

Stopped early · Phase 2

Conditions studied: Asthma, Allergy, Allergic Rhinitis, Rhinitis, Allergic, Seasonal

In brief

This study will test the effectiveness of an investigational treatment for patients with ragweed-induced asthma, sometimes called fall seasonal asthma. The treatment being tested is a series of anti-ragweed shots. The purpose of the study is to determine whether a short series of injections with Amb a 1-immunostimulatory oligodeoxyribonucleotide conjugate (AIC) can cause a long-lasting reduction in the symptoms of asthma that are caused by fall hay fever allergies.

Key facts

Study ID

NCT00318747

Run by

National Institute of Allergy and Infectious Diseases (NIAID)

People needed

140

Starts

2006-04-01

Expected to finish

2006-11-01

Last updated by the study team

2013-02-05

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• History of asthma
• History of asthma medication use during the 2005 fall ragweed season
• Suspected ragweed allergy
• Positive laboratory tests for ragweed allergy

You may not qualify if…

• Received immunotherapy for ragweed or other allergens within the 5 years prior to study entry
• Received anti-IgE (omalizumab) within the year prior to study entry
• 3 or more courses of oral corticosteroids for asthma within the year prior to study entry
• Inpatient hospitalization for asthma within the 5 years prior to study entry
• History of respiratory failure or intubation for asthma
• Smoking within the 6 months prior to study entry
• Greater than 5 pack/year history of smoking
• Clinically significant acute or chronic illness
• Chronic immunodeficiency

Where it is running

• Johns Hopkins University — Baltimore, Maryland, United States
• Bernstein Clinical Research Center, University of Cincinnati — Cincinnati, Ohio, United States
• Optimed Research, Ohio State University — Columbus, Ohio, United States
• Pennsylvania State University — Hershey, Pennsylvania, United States

Full record on ClinicalTrials.gov

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