Enteral Glutamine in Critical Illness

Stopped early · Phase 2/Phase 3

Conditions studied: Critical Illness, Sepsis, Respiratory Insufficiency

In brief

Glutamine is an amino acid which is rapidly depleted in critical illness. It is used as energy by cells that line the gut, vital for immune system function, and works as an anti-oxidant. Glutamine supplementation has been shown to improve outcomes in ICU patients. We hypothesize that critically ill patients given extra glutamine will have less of an inflammatory response and therefore better outcomes than patients not given extra glutamine. Our study randomizes patients to tube feeding with OR without extra glutamine to see if it affects patient outcomes as well as markers of inflammation.

Key facts

Study ID

NCT00318331

Run by

Christiana Care Health Services

People needed

20

Starts

2006-05-01

Expected to finish

2007-09-01

Last updated by the study team

2008-03-13

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Admission to MICU/ CICU
• Age greater than or equal to 18 years old
• Requirement for enteral nutrition
• Presence or planned insertion of central venous catheter as part of routine medical care
• Requirement for mechanical ventilation
• APACHE II Score >/= 15

You may not qualify if…

• Female of child-bearing age (i.e. less than 45 years old)
• Enteral nutrition begun prior to randomization
• Receiving Total Parenteral Nutrition
• Requirement for protein restriction
• Creatinine >4 mg/dl
• History of cirrhosis and/or clinical signs of heptic encephalopathy

Where it is running

• Christiana Hospital — Newark, Delaware, United States

Full record on ClinicalTrials.gov

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