Safety and Efficacy Study to Determine Anti-Asthmatic Effect of Esomeprazole Magnesium; Nexium Reflux Asthma

Completed · Phase 2 · Has a placebo group

Conditions studied: Asthma, GERD

In brief

The purpose of this study is to determine whether treatment with esomeprazole for 6 months will improve asthma in adult patients with moderate to severe asthma and symptoms of gastroesophageal reflux disease.

Key facts

Study ID

NCT00317044

Run by

AstraZeneca

People needed

961

Starts

2006-04-01

Expected to finish

2008-07-01

Last updated by the study team

2014-06-09

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults with diagnosis of asthma since at least 6 months.
• Symptoms of asthma during run-in.
• At least 3 months history and present symptoms of 1 or more of the following: burning feeling behind breastbone, pain behind breastbone, acid taste in the mouth.

You may not qualify if…

• Patients with clinically relevant abnormalities.
• Patients with a smoking history of ≥10 pack-year.
• Patients who have had previous surgery on the esophagus or the stomach.

Where it is running

• Research Site — Scottsdale, Arizona, United States
• Research Site — Little Rock, Arkansas, United States
• Research Site — Fountain Valley, California, United States
• Research Site — Miami, Florida, United States
• Research Site — Atlanta, Georgia, United States
• Research Site — Stockbridge, Georgia, United States
• Research Site — Normal, Illinois, United States
• Research Site — Overland Park, Kansas, United States
• Research Site — Wichita, Kansas, United States
• Research Site — Mandeville, Louisiana, United States
• Research Site — Wheaton, Maryland, United States
• Research Site — St Louis, Missouri, United States
• Research Site — Papillion, Nebraska, United States
• Research Site — Asheville, North Carolina, United States
• Research Site — Cincinnati, Ohio, United States
• Research Site — Sylvania, Ohio, United States
• Research Site — Medford, Oregon, United States
• Research Site — Pittsburgh, Pennsylvania, United States
• Research Site — Upland, Pennsylvania, United States
• Research Site — Charleston, South Carolina, United States
• Research Site — Austin, Texas, United States
• Research Site — Houston, Texas, United States
• Research Site — San Antonio, Texas, United States
• Research Site — Kirkland, Washington, United States
• Research Site — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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