Calcium Gluconate and Magnesium Sulfate in Preventing Neurotoxicity Caused By Oxaliplatin in Patients Receiving Combination Chemotherapy for Stage II, Stage III, or Stage IV Colorectal Cancer That Has Been Completely Removed By Surgery
Completed · Phase 3 · Has a placebo group
Conditions studied: Colorectal Cancer, Neurotoxicity
In brief
RATIONALE: Calcium gluconate and magnesium sulfate may prevent or lessen neurotoxicity caused by oxaliplatin. It is not yet known whether calcium gluconate and magnesium sulfate are more effective than a placebo in preventing neurotoxicity caused by oxaliplatin in patients receiving combination chemotherapy. PURPOSE: This randomized phase III trial is studying calcium gluconate and magnesium sulfate to see how well they work compared to a placebo in preventing neurotoxicity caused by oxaliplatin in patients receiving combination chemotherapy for stage II, stage III, or stage IV colorectal cancer that has been completely removed by surgery.
Key facts
- Study ID
- NCT00316914
- Run by
- Alliance for Clinical Trials in Oncology
- People needed
- 104
- Starts
- 2006-01-01
- Expected to finish
- 2012-11-01
- Last updated by the study team
- 2016-08-11
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- MBCCOP - Medical College of Georgia Cancer Center — Augusta, Georgia, United States
- Mercy Capitol Hospital — Des Moines, Iowa, United States
- CCOP - Iowa Oncology Research Association — Des Moines, Iowa, United States
- John Stoddard Cancer Center at Iowa Methodist Medical Center — Des Moines, Iowa, United States
- Medical Oncology and Hematology Associates at John Stoddard Cancer Center — Des Moines, Iowa, United States
- Medical Oncology and Hematology Associates at Mercy Cancer Center — Des Moines, Iowa, United States
- Mercy Cancer Center at Mercy Medical Center - Des Moines — Des Moines, Iowa, United States
- John Stoddard Cancer Center at Iowa Lutheran Hospital — Des Moines, Iowa, United States
- Bismarck Cancer Center — Bismarck, North Dakota, United States
- Medcenter One Hospital Cancer Care Center — Bismarck, North Dakota, United States
- Mid Dakota Clinic, PC — Bismarck, North Dakota, United States
- Avera Cancer Institute — Sioux Falls, South Dakota, United States
- Medical X-Ray Center, PC — Sioux Falls, South Dakota, United States
- Sanford Cancer Center at Sanford USD Medical Center — Sioux Falls, South Dakota, United States
Full record on ClinicalTrials.gov
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