Cisplatin, Irinotecan, and Radiation Therapy in Treating Patients With Esophageal Cancer or Gastroesophageal Junction Cancer That Can Be Removed By Surgery
Completed · Phase 2
Conditions studied: Esophageal Cancer
In brief
This phase II trial studies how well giving cisplatin and irinotecan hydrochloride together with radiation therapy works in treating patients with esophageal cancer or gastroesophageal junction cancer that can be removed by surgery. Drugs used in chemotherapy, such as cisplatin and irinotecan hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high-energy x-rays to kill tumor cells. Giving combination chemotherapy together with radiation therapy before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be removed.
Key facts
- Study ID
- NCT00316862
- Run by
- Alliance for Clinical Trials in Oncology
- People needed
- 82
- Starts
- 2006-02-01
- Expected to finish
- 2014-10-15
- Last updated by the study team
- 2018-05-08
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- No history of clinically significant ventricular arrhythmia requiring ongoing medication with antiarrhythmics
- Absolute neutrophil count (ANC) >= 1,500/ul
- Platelet count >= 100,000/ul
- Hemoglobin >= 9 gm/dl
- Serum creatinine =< upper limit of normal (ULN)
- Total serum bilirubin =< 1.5 mg/dl
- Forced expiratory volume in 1 second (FEV-1) >= 1.2 liters OR >= 35% of normal as a value that is indexed to body size
- Pulmonary function tests (PFT) >= 1.2 liters OR >= 35% of normal as a value that is indexed to body size
Where it is running
- Elkhart General Hospital — Elkhart, Indiana, United States
- Howard Community Hospital — Kokomo, Indiana, United States
- Center for Cancer Therapy at LaPorte Hospital and Health Services — La Porte, Indiana, United States
- Saint Joseph Regional Medical Center — Mishawaka, Indiana, United States
- CCOP - Northern Indiana CR Consortium — South Bend, Indiana, United States
- Memorial Hospital of South Bend — South Bend, Indiana, United States
- Michiana Hematology-Oncology, PC - South Bend — South Bend, Indiana, United States
- Holden Comprehensive Cancer Center at University of Iowa — Iowa City, Iowa, United States
- CancerCare of Maine at Eastern Maine Medical Center — Bangor, Maine, United States
- Maine Center for Cancer Medicine and Blood Disorders - Scarborough — Scarborough, Maine, United States
- Lakeland Regional Cancer Care Center - St. Joseph — Saint Joseph, Michigan, United States
- Methodist Estabrook Cancer Center — Omaha, Nebraska, United States
- New Hampshire Oncology - Hematology, PA at Payson Center for Cancer Care — Concord, New Hampshire, United States
- New Hampshire Oncology - Hematology, PA - Hooksett — Hooksett, New Hampshire, United States
- Lakes Region General Hospital — Laconia, New Hampshire, United States
- Elliot Regional Cancer Center at Elliot Hospital — Manchester, New Hampshire, United States
- Veterans Affairs Medical Center - Buffalo — Buffalo, New York, United States
- Roswell Park Cancer Institute — Buffalo, New York, United States
- Memorial Sloan-Kettering Cancer Center — New York, New York, United States
- SUNY Upstate Medical University Hospital — Syracuse, New York, United States
- Wayne Memorial Hospital, Incorporated — Goldsboro, North Carolina, United States
- Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at Ohio State University Comprehensive Cancer Center — Columbus, Ohio, United States
- Mountainview Medical — Berlin Corners, Vermont, United States
- Fletcher Allen Health Care - University Health Center Campus — Burlington, Vermont, United States
Full record on ClinicalTrials.gov
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