Study of INS50589 Intravenous Infusion in Subjects Undergoing Coronary Artery Bypass Grafting (CABG) Involving Cardiopulmonary Bypass

Stopped early · Phase 2

Conditions studied: Coronary Disease

In brief

The purpose of this trial is to identify a dose or doses of INS50589 intravenous infusion that are well-tolerated and which reduce postoperative bleeding and blood product transfusion.

Key facts

Study ID

NCT00316212

Run by

Merck Sharp & Dohme LLC

People needed

160

Starts

2006-04-01

Last updated by the study team

2016-11-18

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Are scheduled for primary CABG by median sternotomy involving cardiopulmonary bypass
• Willing to receive allogeneic blood product transfusions during and after surgery

You may not qualify if…

• Have had previous cardiac surgery
• Have had previous median sternotomy
• Have tendency for bleeding or family history of bleeding
• Have an abnormally low platelet count
• Have received certain anticoagulant or antiplatelet medications within a specified time period prior to the scheduled CABG surgery

Where it is running

• Baptist Medical Center Princeton — Birmingham, Alabama, United States
• Cardiology, P.C. — Birmingham, Alabama, United States
• Sharp Memorial Hospital — San Diego, California, United States
• Memorial Medical Center — Springfield, Illinois, United States
• St. John's Hospital — Springfield, Illinois, United States
• Southern Illinois University School of Medicine — Springfield, Illinois, United States
• Lutheran Hospital of Indiana — Fort Wayne, Indiana, United States
• Veterans Affairs Medical Center — Lexington, Kentucky, United States
• University of Kentucky, Chandler Medical Center — Lexington, Kentucky, United States
• St. Mary's of Michigan — Saginaw, Michigan, United States
• Covenant Medical Center — Saginaw, Michigan, United States
• Viahealth Rochester General Hospital — Rochester, New York, United States
• Duke University Medical Center — Durham, North Carolina, United States
• The Brody School of Medicine, East Carolina University — Greenville, North Carolina, United States
• Cardiac, Vascular, & Thoracic Surgeons, Inc. — Cincinnati, Ohio, United States
• Good Samaritan Hospital — Cincinnati, Ohio, United States
• Bethesda North Hospital — Cincinnati, Ohio, United States
• Oklahoma Cardiovascular Associates — Oklahoma City, Oklahoma, United States
• Oklahoma Cardiovascular Research Group — Oklahoma City, Oklahoma, United States
• Oklahoma Heart Hospital — Oklahoma City, Oklahoma, United States
• CardioThoracic Surgery Center, PLC — Jackson, Tennessee, United States
• Jackson Madison County General Hospital — Jackson, Tennessee, United States
• Centennial Medical Center — Nashville, Tennessee, United States
• The Methodist Hospital — Houston, Texas, United States
• Winchester Medical Center — Winchester, Virginia, United States

Full record on ClinicalTrials.gov

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