Determining Disease Activity Biomarkers in Individuals With Takayasu's Arteritis

Completed

Conditions studied: Takayasu's Arteritis

In brief

Takayasu's arteritis is a rare disorder that causes swelling and damage to the large arteries in the body, such as the aorta. In order to ensure proper treatment, measuring disease activity is critical. The purpose of this study is to establish new biological markers (biomarkers) to assess the severity of disease in people with Takayasu's arteritis.

Key facts

Study ID

NCT00315471

Run by

University of Pennsylvania

People needed

224

Starts

2006-04-01

Expected to finish

2019-12-01

Last updated by the study team

2022-07-12

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Evidence of arteriogram abnormalities compatible with Takayasu's arteritis (includes conventional dye angiography, magnetic resonance angiography, or computed tomography angiography)
• Evidence of one of the following criteria:
• Age at disease onset of 50 years or younger
• Claudication of the arms or legs
• Decreased brachial artery pulse (one or both arteries)
• Blood pressure difference between the arms of at least 10 mm Hg
• Bruit over the subclavian arteries or aorta
• Parental consent for children under the age of 18

You may not qualify if…

• Arteriographic lesions that could be entirely due to atherosclerosis
• Fibromuscular dysplasia
• Cogan's syndrome
• Behcet's disease
• Sarcoidosis
• Kawasaki disease
• Giant cell arteritis (large vessel vasculitis and at least 50 years old)
• Syphilis or other infectious forms of large vessel vasculitis

Where it is running

• Brigham and Women's Hospital — Boston, Massachusetts, United States
• Boston University School of Medicine — Boston, Massachusetts, United States
• Mayo Clinic College of Medicine — Rochester, Minnesota, United States
• Cleveland Clinic Foundation — Cleveland, Ohio, United States
• University of Pennsylvania — Philadelphia, Pennsylvania, United States
• University of Pittsburgh — Pittsburgh, Pennsylvania, United States
• University of Utah — Salt Lake City, Utah, United States
• St. Joseph's Healthcare — Hamilton, Ontario, Canada
• Mount Sinai Hospital — Toronto, Ontario, Canada

Full record on ClinicalTrials.gov

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