Longitudinal Study for Eosinophilic Granulomatosis With Polyangiitis

Recruiting now

Conditions studied: Eosinophilic Granulomatosis With Polyangiitis, Churg-Strauss Syndrome

In brief

Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare immune system disorder that causes asthma, an excessive number of eosinophils (a type of white blood cell) in the blood, and the inflammation of blood vessels, or vasculitis. In order to properly treat EGPA, it is critical that the level of disease activity can be determined over the course of the disease. The purpose of this study is to determine new biological markers, or biomarkers, that may be used to assess the severity of this disease in people with EGPA.

Key facts

Study ID

NCT00315380

Run by

University of Pennsylvania

People needed

700

Starts

2006-04-01

Expected to finish

2028-12-01

Last updated by the study team

2026-01-23

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with a diagnosis of eosinophilic granulomatosis with polyangiitis are eligible for the study.
• Parent or guardian willing to provide informed consent, if applicable

You may not qualify if…

• Inability to give informed consent and to sign the consent form

Where it is running

• St. Joseph's Healthcare — Hamilton, Ontario, Canada (enrolling)
• medius KLINIK KIRCHHEIM — Kirchheim unter Teck, Germany (enrolling)
• AOU Meyer IRCCS — Florence, Italy (enrolling)
• Imperial College Healthcare NHS Trust/ Imperial College London — London, United Kingdom (enrolling)
• Cleveland Clinic Foundation — Cleveland, Ohio, United States
• University of Pennsylvania — Philadelphia, Pennsylvania, United States
• University of California San Diego — San Diego, California, United States
• University of Utah — Salt Lake City, Utah, United States
• Mount Sinai Hospital — Toronto, Ontario, Canada
• University of Pittsburgh — Pittsburgh, Pennsylvania, United States
• National Jewish Health — Denver, Colorado, United States
• Brigham and Women's Hospital — Boston, Massachusetts, United States
• Mayo Clinic — Rochester, Minnesota, United States

Full record on ClinicalTrials.gov

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