Optimizing Body Composition for Function in Older Adults

Completed · Phase 4 · Has a placebo group

Conditions studied: Obesity, Overweight With Indications for Weight Loss

In brief

The purpose of this pilot study is to compare two strategies intended to improve the health of overweight older adults by improving body composition. One strategy, resistance training, is designed to preserve skeletal muscle mass. The other strategy, the use of a PPAR-γ agonist, is designed to enhance the loss of fat from visceral and skeletal depots. These strategies will be used in conjunction with a hypocaloric diet and will be compared to a hypocaloric diet alone to determine if either of these strategies are superior in reducing visceral fat and preserving muscle mass.

Key facts

Study ID

NCT00315146

Run by

Wake Forest University Health Sciences

People needed

88

Starts

2006-04-01

Expected to finish

2007-04-01

Last updated by the study team

2018-08-28

Who can join

Age: 65 and older, up to 79. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Weight Stable, Indication for weight loss per NIH guidelines, Performance on the short physical performance battery score 3-10

You may not qualify if…

• Diabetes, weight > 136 kg, Medical condition that limits exercise participation, Congestive heart failure, abnormal kidney function, higher ALT than normal, currently involved in a weight loss or exercise program, current smoking, alcohol or drug abuse, taking anti-inflammatory steroids, taking protein supplements, taking PPAR-gamma agonist, edema, anemia

Where it is running

• Sticht Center on Aging, Wake Forest University Baptist Medical Center — Winston-Salem, North Carolina, United States

Full record on ClinicalTrials.gov

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