Safety Study of Seneca Valley Virus in Patients With Solid Tumors With Neuroendocrine Features

Status unconfirmed · Phase 1

Conditions studied: Carcinoid, Neuroendocrine

In brief

The primary purpose of the study is to determine if Seneca Valley Virus may be administered safely to patients with certain types of advanced cancer.

Key facts

Study ID

NCT00314925

Run by

Neotropix

People needed

60

Starts

2006-04-01

Expected to finish

2008-12-01

Last updated by the study team

2010-02-25

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients must have a histologically confirmed solid tumor (including carcinoid) with neuroendocrine features (i.e., expression of >= 1 of the following 3 markers: synaptophysin, chromogranin A, or CD56) that is metastatic or unresectable and for which standard curative or palliative measures do not exist or are no longer effective.
• Patients must show evidence of disease progression in the three months prior to treatment with SVV-001.
• Age >= 18 years. Because no dosing or adverse event data are currently available on the use of SVV-001 in patients <18 years of age, children are excluded from this study. Children may be eligible for future pediatric Phase I single-agent trials.
• Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1.
• Life expectancy >= 24 weeks.
• Adequate bone marrow, hepatic, and renal function as defined below:
• absolute lymphocyte count >= 1,000/ul
• absolute neutrophil count >= 1,500/ul
• platelets >= 100,000/ul
• AST/ALT <= 2.5 x upper limit of normal (ULN) or <= 5 x ULN if liver metastases present
• total bilirubin <= 1.5 x upper limit of normal
• creatinine <= 1.5 x upper limit of normal OR
• creatinine clearance (calculated) <= 60 mL/min/1.73 m2 for patients with creatinine > 1.5 x upper limit of normal.
• Women must have been surgically sterilized or be post-menopausal.
• Men must agree to use adequate contraception (barrier method of birth control; abstinence) prior to study entry and for up to 6 months.
• Ability to understand and the willingness to sign a written informed consent document.
• Patients must have oxygen saturation of at least 95% on room air.
• Patients must have measurable disease by RECIST (CT and/or MRI).

You may not qualify if…

• Patients with small cell histology.
• Patients who have been hospitalized for emergent conditions requiring inpatient evaluation, treatment or procedure during the 30 days prior to entry on study. In addition, emergent conditions requiring inpatient evaluation, treatment or procedure must have resolved or be medically stable and not severe for 30 days prior to entry on study.
• Use of chemotherapy or radiotherapy within 4 weeks of initiation of SVV-001, or continued > Grade 1 adverse events, excluding alopecia, due to agents administered more than 4 weeks earlier.
• Patients with clinically evident Human Immuno-deficiency Virus (HIV), Hepatitis B Virus (HBV) or Hepatitis C Virus (HCV) infection.
• Patients with > Grade 1 peripheral neuropathy (CTCAE version 3.0).
• Concurrent use of any other investigational agents.
• Presence of or history of central nervous system metastasis.
• Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
• Pre-menopausal women who have not been surgically sterilized. Although SVV-001 has no affect on the ovaries from a toxicological perspective, SVV-001 RNA is present in the ovaries at 12 weeks in animals that were administered high and medium doses. No pre-clinical reproductive tests have been conducted with SVV-001.

Where it is running

• Cancer Centers of Florida — Ocoee, Florida, United States
• Central Indiana Cancer Centers — Indianapolis, Indiana, United States
• The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins — Baltimore, Maryland, United States
• New York Oncology Hematology P.C. — Albany, New York, United States
• Dayton Oncology & Hematology, P.A . — Kettering, Ohio, United States
• Cancer Centers of the Carolinas — Greenville, South Carolina, United States
• Mary Crowley Research Center — Dallas, Texas, United States
• Tyler Cancer Center — Tyler, Texas, United States
• Virginia Oncology Associates — Norfolk, Virginia, United States
• Northwest Cancer Specialists - Vancouver Cancer Center — Vancouver, Washington, United States

Full record on ClinicalTrials.gov

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