Randomized Ph 2 Trial Of Paclitaxel/Carboplatin /Bevacizumab + PF-3512676 And P/C/B Alone In Advanced Nonsquamous NSCLC

Stopped early · Phase 2

Conditions studied: Carcinoma, Non-Small-Cell Lung

In brief

To assess the efficacy and safety of PF-3512676 administered in combination with paclitaxel, carboplatin and bevacizumab as first-line treatment in patients with locally advanced or metastatic nonsquamous non-small cell lung cancer

Key facts

Study ID

NCT00313768

Run by

Pfizer

People needed

23

Starts

2005-12-01

Expected to finish

2008-05-01

Last updated by the study team

2009-09-28

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Advanced Stage IIIb with pleural effusion or Stage IV nonsquamous non-small cell lung cancer
• ECOG Performance Status 0-1
• Measurable disease per RECIST criteria

You may not qualify if…

• Squamous cell, small cell, or carcinoid lung cancer
• CNS metastasis
• Pre-existing autoimmune or antibody mediated disease
• Prior systemic treatment for NSCLC with chemo, immunotherapy, biologics, or investigation drugs

Where it is running

• Pfizer Investigational Site — Bessemer, Alabama, United States
• Pfizer Investigational Site — Birmingham, Alabama, United States
• Pfizer Investigational Site — Birmingham, Alabama, United States
• Pfizer Investigational Site — Birmingham, Alabama, United States
• Pfizer Investigational Site — Birmingham, Alabama, United States
• Pfizer Investigational Site — Birmingham, Alabama, United States
• Pfizer Investigational Site — Mobile, Alabama, United States
• Pfizer Investigational Site — Fountain Valley, California, United States
• Pfizer Investigational Site — Los Angeles, California, United States
• Pfizer Investigational Site — Cocoa Beach, Florida, United States
• Pfizer Investigational Site — Merritt Island, Florida, United States
• Pfizer Investigational Site — Rockledge, Florida, United States
• Pfizer Investigational Site — Titusville, Florida, United States
• Pfizer Investigational Site — Valdosta, Georgia, United States
• Pfizer Investigational Site — Joliet, Illinois, United States
• Pfizer Investigational Site — Joliet, Illinois, United States
• Pfizer Investigational Site — Baltimore, Maryland, United States
• Pfizer Investigational Site — Clinton, North Carolina, United States
• Pfizer Investigational Site — Goldsboro, North Carolina, United States
• Pfizer Investigational Site — Pollocksville, North Carolina, United States
• Pfizer Investigational Site — Wilson, North Carolina, United States
• Pfizer Investigational Site — Knoxville, Tennessee, United States
• Pfizer Investigational Site — Knoxville, Tennessee, United States
• Pfizer Investigational Site — Austin, Texas, United States
• Pfizer Investigational Site — Austin, Texas, United States

Full record on ClinicalTrials.gov

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