Irinotecan and Temozolomide in Treating Young Patients With Recurrent Neuroblastoma

Completed · Phase 2

Conditions studied: Neuroblastoma

In brief

RATIONALE: Drugs used in chemotherapy, such as irinotecan and temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more tumor cells. PURPOSE: This phase II trial is studying how well giving irinotecan together with temozolomide works in treating young patients with recurrent neuroblastoma.

Key facts

Study ID

NCT00311584

Run by

Children's Oncology Group

People needed

59

Starts

2006-04-01

Expected to finish

2013-12-01

Last updated by the study team

2014-09-30

Who can join

Age: any, up to 21. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Arizona Cancer Center at University of Arizona Health Sciences Center — Tucson, Arizona, United States
• Arkansas Cancer Research Center at University of Arkansas for Medical Sciences — Little Rock, Arkansas, United States
• Southern California Permanente Medical Group — Downey, California, United States
• Loma Linda University Cancer Institute at Loma Linda University Medical Center — Loma Linda, California, United States
• Jonathan Jaques Children's Cancer Center at Miller Children's Hospital — Long Beach, California, United States
• Childrens Hospital Los Angeles — Los Angeles, California, United States
• Children's Hospital Central California — Madera, California, United States
• Children's Hospital and Research Center Oakland — Oakland, California, United States
• Children's Hospital of Orange County — Orange, California, United States
• Sutter Cancer Center — Sacramento, California, United States
• Kaiser Permanente Medical Center - Oakland — Sacramento, California, United States
• UCSF Helen Diller Family Comprehensive Cancer Center — San Francisco, California, United States
• Stanford Cancer Center — Stanford, California, United States
• Children's Hospital Center for Cancer and Blood Disorders — Aurora, Colorado, United States
• Carole and Ray Neag Comprehensive Cancer Center at the University of Connecticut Health Center — Farmington, Connecticut, United States
• Alfred I. duPont Hospital for Children — Wilmington, Delaware, United States
• Children's National Medical Center — Washington D.C., District of Columbia, United States
• Lee Cancer Care of Lee Memorial Health System — Fort Myers, Florida, United States
• University of Florida Shands Cancer Center — Gainesville, Florida, United States
• Nemours Children's Clinic — Jacksonville, Florida, United States
• University of Miami Sylvester Comprehensive Cancer Center - Miami — Miami, Florida, United States
• Miami Children's Hospital — Miami, Florida, United States
• Florida Hospital Cancer Institute at Florida Hospital Orlando — Orlando, Florida, United States
• Sacred Heart Cancer Center at Sacred Heart Hospital — Pensacola, Florida, United States
• Lurleen Wallace Comprehensive Cancer at University of Alabama - Birmingham — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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