Hepatic Drug Biotransformation in Children With Obstructive Sleep Apnea

Completed · Not applicable

Conditions studied: Sleep Apnea

In brief

The purpose of this research study is to determine the effect of chronic nighttime low oxygen saturations on selected body systems (liver) that break down drugs in children with obstructive sleep apnea syndrome (OSAS).

Key facts

Study ID

NCT00310323

Run by

Virginia Commonwealth University

People needed

69

Starts

2003-01-01

Expected to finish

2006-02-01

Last updated by the study team

2009-03-19

Who can join

Age: 4 and older, up to 16. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Children ages 4 to 16 years with suspected uncomplicated OSAS

You may not qualify if…

• Children with complicated OSAS (craniofacial abnormalities, neuromuscular disorders)
• Children who are receiving medications known to induce or inhibit hepatic CYP1A2, NAT-2, XO, CYP2D6 or CYP3A4 activity
• Children who are exposed to second hand smoke for greater than 8 hours per day.
• Children with hypersensitivity to caffeine or dextromethorphan
• Children who are receiving corticosteroids or thyroid hormone

Where it is running

• University of Louisville — Louisville, Kentucky, United States
• Virginia Commonwealth University — Richmond, Virginia, United States

Full record on ClinicalTrials.gov

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