Study of Pantoprazole for Sleepiness Associated With Acid Reflux and Sleep Apnea

Completed · Phase 4

Conditions studied: Acid Reflux Disease, Obstructive Sleep Apnea

In brief

The purpose of this study is to determine if using Pantoprazole decreases your daytime sleepiness and improves your reaction time when compared to using a placebo (sugar pill).

Key facts

Study ID

NCT00307944

Run by

University of Cincinnati

People needed

68

Starts

2004-08-01

Expected to finish

2006-08-01

Last updated by the study team

2007-12-12

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 18 or older
• Daytime sleepiness (ESS >= 8)
• Mild to moderate OSD (AHI<=30)
• Symptoms of GERD
• Symptoms of acid reflux

You may not qualify if…

• Pregnant or trying to become pregnant
• Depression or unstable psychiatric disorder
• Allergy to Pantoprazole
• Taking a proton pump inhibitor within the last month
• Taking a histamine-2 receptor blocker within the last month
• Automobile or industrial accident due to daytime sleepiness
• Currently taking ketoconazole, itraconazole, ampicillin or iron salts
• Hypersecretory acid disorder (Zollinger-Ellison Syndrome)
• Active peptic ulcer disease
• Severe concomitant disease of another major body system
• Malignancy in the past 5 years
• Current abuse of alcohol, medication or drugs
• Sedative medications
• Additional treatment for obstructive sleep apnea (i.e. CPAP or surgery)

Where it is running

• University Ear, Nose and Throat Specialists — Cincinnati, Ohio, United States

Full record on ClinicalTrials.gov

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