Safety and Effectiveness of Sustained Release Bupropion in Treating Individuals With Schizophrenia Who Smoke

Completed · Phase 4 · Has a placebo group

Conditions studied: Tobacco-Use Disorder, Schizophrenia, Psychotic Disorders

In brief

Many individuals with schizophrenia smoke cigarettes. Individuals in the schizophrenic population often find it difficult to quit smoking. The purpose of this trial is to determine the safety and effectiveness of bupropion in treating individuals with schizophrenia who smoke.

Key facts

Study ID

NCT00307203

Run by

National Institute on Drug Abuse (NIDA)

People needed

51

Starts

1998-08-01

Expected to finish

2004-02-01

Last updated by the study team

2017-01-11

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Meets DSM-IV criteria for schizophrenia or schizoaffective disorder
• Receiving a stable dose of antipsychotic medication for at least 1 month prior to study entry
• Smokes at least 10 cigarettes per day
• Wishes to stop smoking
• Attended last three scheduled clinic visits, prior to study entry

You may not qualify if…

• Significant medical or neurologic illness
• History of severe head injury with loss of consciousness
• Treated with monoamine oxidase inhibitors or carbamazepine in the 14 days prior to study entry
• Taking clozapine at doses greater than 500 mg/d without an anticonvulsant
• Currently undergoing an acute exacerbation of psychotic symptoms
• Current or history of bulimia or anorexia
• Current excessive water intake
• Recent history of mania
• Known allergy or hypersensitivity to bupropion
• Current substance abuse other than tobacco, nicotine replacement treatment, or smokeless tobacco
• Currently receiving treatment with bupropion
• Pregnant or breastfeeding

Where it is running

• Freedom Trail Clinic — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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