Trial of Magnesium Sulfate Tocolysis Versus Nifedipine Tocolysis in Women With Preterm Labor

Stopped early · Not applicable · Has a placebo group

Conditions studied: Premature Birth, Premature Labor

In brief

Primary Hypothesis: Acute tocolysis (48 hours) using oral nifedipine is more effective than intravenous magnesium sulfate in prolonging pregnancy in women with preterm labor with intact membranes between 24 and 32 6/7 weeks' gestation.

Key facts

Study ID

NCT00306462

Run by

University of Cincinnati

People needed

33

Starts

2006-03-01

Expected to finish

2009-10-01

Last updated by the study team

2009-11-09

Who can join

Age: 15 and older, up to 50. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Women in preterm labor between 24 to 32 6/7 weeks' gestation with intact membranes with an age range of 15 to 50 years old.

You may not qualify if…

• Cervical dilatation of ≥ 6 cm
• Maternal contraindication to tocolysis
• Known fetal anomalies
• Suspected chorioamnionitis
• Nonreassuring fetal heart tracing
• Vaginal bleeding due to placenta previa or abruptio placenta
• Preterm premature rupture of membranes
• Prolapsed membranes
• Human immunodeficiency virus positive
• Multiple gestation
• Patients on procardia within 24 hours of po intake
• Magnesium sulfate tocolysis prior to randomization
• Patient refusal

Where it is running

• University Hospital — Cincinnati, Ohio, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.