Long Term Effects of Hydroxyurea Therapy in Children With Sickle Cell Disease

Completed

Conditions studied: Sickle Cell Disease

In brief

The primary objectives of this prospective, observational study are (1) to describe the long-term cellular, molecular, and clinical effects of hydroxyurea therapy in sickle cell disease, and (2) to perform hydroxyurea pharmacokinetics studies. This study will follow sickle cell patients being treated with hydroxyurea for a long period of time to evaluate the long-term cellular and molecular effects of the drug on the patients' body. This study will consist of two patient groups. One group will be made up of patients who have received hydroxyurea therapy before entering the study. The second group will be made up of patients who have not received hydroxyurea before study entry.

Key facts

Study ID

NCT00305175

Run by

St. Jude Children's Research Hospital

People needed

260

Starts

2006-03-03

Expected to finish

2015-04-23

Last updated by the study team

2020-07-28

Who can join

Age: any, up to 30. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients from birth up to age 30 years
• Diagnosis of sickle cell disease
• Patients who are receiving hydroxyurea therapy or plan to begin hydroxyurea therapy

Where it is running

• St. Jude Children's Research Hospital — Memphis, Tennessee, United States

Full record on ClinicalTrials.gov

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