Dynamic Light Scattering to Study Crystalline Proteins in Young Normal Lenses

Completed

Conditions studied: Healthy

In brief

This study will use a method called dynamic light scattering (DLS) to study the lens of the eye in young normal subjects. The DLS device uses a very dim laser light to study the lens of the eye. It detects proteins in the lens, identifying early changes that may make the device useful in future cataract studies. This study will use DLS to examine the characteristics of proteins in healthy young lenses that can be used for comparison with lenses in older people and people with cataracts. Normal volunteers aged 5 to 21 years may be eligible for this study. Participants undergo the following procedures: Medical history Eye examination with dilation to include: * Measurement of visual acuity * Examination of pupils and eye movements * Examination of the front of the eye (cornea, lens) with a slit lamp bio-microscope * Examination of retina with an ophthalmoscope (instrument with a strong light and magnifying lens) * Dynamic light scattering

Key facts

Study ID

NCT00304967

Run by

National Eye Institute (NEI)

People needed

30

Starts

2006-03-15

Expected to finish

2007-03-31

Last updated by the study team

2017-07-02

Who can join

Age: 5 and older, up to 21. Sex: any. Healthy volunteers: accepted.

You may not qualify if…

• Individuals who cannot cooperate or keep still for the DLS measurements will be excluded.

Where it is running

• National Institutes of Health Clinical Center, 9000 Rockville Pike — Bethesda, Maryland, United States

Full record on ClinicalTrials.gov

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