Effectiveness of Bupropion for Smokers Recovering From Alcohol Dependence

Completed · Phase 3 · Has a placebo group

Conditions studied: Smoking Cessation, Alcohol-Related Disorders

In brief

Smoking is often a problem for alcohol dependent individuals. Many people who seek treatment for alcohol dependence are unable to quit smoking. The purpose of this study is to evaluate the effectiveness of bupropion, an antidepressant medication, in treating smokers receiving treatment for alcohol dependence.

Key facts

Study ID

NCT00304707

Run by

National Institute on Drug Abuse (NIDA)

People needed

143

Starts

2005-04-01

Expected to finish

2011-02-01

Last updated by the study team

2017-05-15

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Smokes a minimum of 10 cigarettes daily for at least 1 year prior to study entry
• Abstinence from alcohol and other non-nicotine drugs for between 1 and 12 months at time of study entry
• Meets criteria for alcohol dependence or abuse in the 12 months prior to study entry

You may not qualify if…

• History of seizures, head trauma and/or severe hepatic cirrhosis
• Current use of medications known to affect smoking behavior and/or cessation
• Use of tricyclic antidepressant medication and monoamine oxidase inhibitors
• Major depressive disorder within the month prior to study entry
• Eating disorder within the year prior to study entry
• History of bipolar or psychotic disorder
• Pregnant or breastfeeding
• Unstable serious medical disorder
• History of migraines
• Currently using smokeless tobacco, pipes, or cigars

Where it is running

• ENRM Veterans Hospital — Bedford, Massachusetts, United States

Full record on ClinicalTrials.gov

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