Humoral Determinants of Immunity to Pneumococcal Infection

Completed · Phase 4

Conditions studied: Pneumonia, Pneumococcal Infections, Infections, Streptococcus Pneumoniae

In brief

The purpose of this study is to determine whether there are differences in the level of antibody to capsular polysaccharides of S. pneumoniae or the physiological activity of such antibody after vaccinating patients who have recovered from pneumococcal pneumonia with pneumococcal polysaccharide vaccine (Pneumovax) or conjugate pneumococcal vaccine (Prevnar).

Key facts

Study ID

NCT00304382

Run by

VA Office of Research and Development

People needed

114

Starts

2003-01-01

Expected to finish

2012-06-01

Last updated by the study team

2017-09-05

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of pneumococcal pneumonia
• Age matched controls who have not had pneumococcal pneumonia
• Patients enrolled must be veterans

You may not qualify if…

• Patients who do not have the diagnosis of pneumococcal pneumonia based on a clinical syndrome that is consistent with pneumonia and the finding of pneumococcus in blood or sputum or any other sterile site will be excluded
• Women of child-bearing age will be excluded
• Patients who have had a prior reaction to pneumococcal vaccine that they describe as 'severe' will be excluded

Where it is running

• Michael E. DeBakey VA Medical Center, Houston, TX — Houston, Texas, United States

Full record on ClinicalTrials.gov

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