Effectiveness of Antibiotic Treatment for Reducing Binge Eating and Improving Digestive Function in Bulimia Nervosa
Completed · Phase 2 · Has a placebo group
Conditions studied: Bulimia Nervosa, Eating Disorders
In brief
This study will determine the effectiveness of the antibiotic erythromycin in enhancing gastrointestinal function and decreasing the frequency of binge eating in people with bulimia nervosa.
Key facts
- Study ID
- NCT00304187
- Run by
- New York State Psychiatric Institute
- People needed
- 29
- Starts
- 2004-09-01
- Expected to finish
- 2011-11-01
- Last updated by the study team
- 2018-08-20
Who can join
Age: 18 and older, up to 55. Sex: female. Healthy volunteers: accepted.
You may qualify if…
- Meets criteria for bulimia nervosa
- Duration of illness is greater than 1 year
- Self-induces vomiting
- Weighs 80%-120 % of ideal weight
You may not qualify if…
- Significant medical illness
- Current or lifetime history of schizophrenia, bipolar disorder, or other psychotic disorder, as defined by American Psychiatric Association criteria
- Moderate to severe depression, as defined by a score greater than 18 on the Hamilton Depression Scales
- Current diagnosis of organic mental disorder, factitious disorder, or malingering
- History of a personality disorder (e.g., schizotypal, borderline, or antisocial) that might interfere with assessment or compliance with the study procedures
- At risk for suicide
- Current psychotropic medications and current medications that affect GI function or that inhibit or induce cytochrome three A gene expression
- Currently pregnant, lactating, or planning to become pregnant
- Drug or alcohol abuse within the 3 months prior to study entry
- Abnormal EKG at baseline or 1 week following each upward dosage adjustment
- Anemia
- Known intolerance to erythromycin, or related antibiotics
- Abnormal results on liver function tests
- Electrolyte abnormalities
Where it is running
- Eating Disorders Clinic, New York State Psychiatric Institute — New York, New York, United States
Full record on ClinicalTrials.gov
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