Combination Chemotherapy in Treating Patients With Stage III or Stage IV Malignant Peripheral Nerve Sheath Tumors
Completed · Phase 2
Conditions studied: Neurofibromatosis Type 1, Sarcoma
In brief
RATIONALE: Drugs used in chemotherapy, such as doxorubicin, ifosfamide, and etoposide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high-energy x-rays to kill tumor cells. Giving combination chemotherapy with or without radiation therapy before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be removed. Giving combination chemotherapy after surgery may kill any tumor cells that remain after surgery. PURPOSE: This phase II trial is studying how well combination chemotherapy works in treating patients with stage III or stage IV malignant peripheral nerve sheath tumors.
Key facts
- Study ID
- NCT00304083
- Run by
- Sarcoma Alliance for Research through Collaboration
- People needed
- 48
- Starts
- 2005-12-01
- Expected to finish
- 2014-06-01
- Last updated by the study team
- 2018-09-18
Who can join
Age: any. Sex: any. Healthy volunteers: not accepted.
Where it is running
- UAB Comprehensive Cancer Center — Birmingham, Alabama, United States
- Sarcoma Oncology Center — Santa Monica, California, United States
- Children's Memorial Hospital - Chicago — Chicago, Illinois, United States
- Indiana University — Indianapolis, Indiana, United States
- University of Iowa Hospitals and Clinics — Iowa City, Iowa, United States
- Johns Hopkins — Baltimore, Maryland, United States
- Warren Grant Magnuson Clinical Center - NCI Clinical Trials Referral Office — Bethesda, Maryland, United States
- University of Michigan Comprehensive Cancer Center — Ann Arbor, Michigan, United States
- University of Minnesota — Minneapolis, Minnesota, United States
- Carolinas Hematology-Oncology Associates — Charlotte, North Carolina, United States
- Cincinnati Children's Hospital Medical Center — Cincinnati, Ohio, United States
- Children's Hospital of Philadelphia — Philadelphia, Pennsylvania, United States
- Pennsylvania Oncology Hematology Associates — Philadelphia, Pennsylvania, United States
- Children's Hospital of Pittsburgh — Pittsburgh, Pennsylvania, United States
- M. D. Anderson Cancer Center at University of Texas — Houston, Texas, United States
- Huntsman Cancer Institute at University of Utah — Salt Lake City, Utah, United States
- Seattle Cancer Care Alliance at Washington University — Seattle, Washington, United States
Full record on ClinicalTrials.gov
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