Monoclonal Antibody Therapy and Combination Chemotherapy in Treating Patients With Stage II, Stage III, or Stage IV Diffuse Large B-Cell Lymphoma
Completed · Phase 2
Conditions studied: Lymphoma
In brief
RATIONALE: Monoclonal antibodies, such as epratuzumab and rituximab, can block cancer growth in different ways. Some block the ability of cancer cells to grow and spread. Others find cancer cells and help kill them or carry cancer-killing substances to them. Drugs used in chemotherapy, such as cyclophosphamide, doxorubicin, vincristine, and prednisone, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving monoclonal antibody therapy together with chemotherapy may kill more cancer cells.\> PURPOSE: This phase II trial is studying how well giving monoclonal antibody therapy together with combination chemotherapy works in treating patients with stage II, stage III, or stage IV diffuse large B-cell lymphoma.
Key facts
- Study ID
- NCT00301821
- Run by
- Alliance for Clinical Trials in Oncology
- People needed
- 107
- Starts
- 2006-01-01
- Expected to finish
- 2015-04-01
- Last updated by the study team
- 2019-10-09
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Porter Adventist Hospital — Denver, Colorado, United States
- Presbyterian - St. Luke's Medical Center — Denver, Colorado, United States
- St. Joseph Hospital — Denver, Colorado, United States
- Rose Medical Center — Denver, Colorado, United States
- CCOP - Colorado Cancer Research Program — Denver, Colorado, United States
- Swedish Medical Center — Englewood, Colorado, United States
- Front Range Cancer Specialists — Fort Collins, Colorado, United States
- St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center — Grand Junction, Colorado, United States
- Sky Ridge Medical Center — Lone Tree, Colorado, United States
- Hope Cancer Care Center at Longmont United Hospital — Longmont, Colorado, United States
- St. Mary - Corwin Regional Medical Center — Pueblo, Colorado, United States
- North Suburban Medical Center — Thornton, Colorado, United States
- Exempla Lutheran Medical Center — Wheat Ridge, Colorado, United States
- Mayo Clinic - Jacksonville — Jacksonville, Florida, United States
- Rush-Copley Cancer Care Center — Aurora, Illinois, United States
- St. Joseph Medical Center — Bloomington, Illinois, United States
- Graham Hospital — Canton, Illinois, United States
- Memorial Hospital — Carthage, Illinois, United States
- Eureka Community Hospital — Eureka, Illinois, United States
- Galesburg Clinic — Galesburg, Illinois, United States
- Galesburg Cottage Hospital — Galesburg, Illinois, United States
- Mason District Hospital — Havana, Illinois, United States
- Hopedale Medical Complex — Hopedale, Illinois, United States
- Joliet Oncology-Hematology Associates, Limited - West — Joliet, Illinois, United States
- Penrose Cancer Center at Penrose Hospital — Colorado Springs, Colorado, United States
Full record on ClinicalTrials.gov
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