Trial of Memantine for Cognitive Impairment in Multiple Sclerosis

Completed · Phase 2/Phase 3

Conditions studied: Multiple Sclerosis, Cognition Disorders

In brief

This study is designed to determine whether memantine is an effective treatment for memory and cognitive problems associated with multiple sclerosis when compared to placebo.

Key facts

Study ID

NCT00300716

Run by

Oregon Health and Science University

People needed

82

Starts

2004-04-01

Expected to finish

2009-01-01

Last updated by the study team

2019-10-15

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• A diagnosis of multiple sclerosis as defined by the McDonald criteria. Patients with relapsing-remitting, secondary progressive, and primary progressive forms of MS are eligible.
• Age between 18 and 65 years.
• Demonstrated cognitive dysfunction at screening defined as a score worse than 1.0 standard deviations below the mean on the PASAT or the CVLT-II.

You may not qualify if…

• A history of major depression, psychosis, or a score > 19 on the Beck's Depression Inventory.
• Corrected binocular visual acuity worse than 20/50; any impairment of binocular color vision.
• Patients that do not speak English as a primary language (fluency may impact performance).
• A clinically significant MS exacerbation within 30 days of the screening
• Pregnancy
• Renal insufficiency.
• History of seizures.
• Patients using acetazolamide (Diamox, Ak-sol, Storzolamide), dichlorphenamide (Daranide), methazolamide (Neptazane) or topiramate (Topamax), dextromethorphan (Robitussin DM and other cold remedies), or amantadine (Symmetrel).
• Use of medical marijuana in the prior six months.
• History of alcohol abuse or illicit drug use in the prior six months.

Where it is running

• USC — Los Angeles, California, United States
• OHSU — Portland, Oregon, United States
• UT Southwestern — Dallas, Texas, United States
• MS Hub — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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