Long-Term Results in Mechanically Ventilated Individuals With Acute Lung Injury/Acute Respiratory Distress Syndrome
Completed
Conditions studied: Respiratory Distress Syndrome, Adult
In brief
Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a severe lung condition that causes respiratory failure. Individuals with ALI/ARDS often require the use of a respirator or artificial breathing machine, known as a mechanical ventilator, while in an intensive care unit (ICU). Past research has shown that improved short-term clinical outcomes result from the use of a protective mechanical ventilation technique for the lungs. This study will evaluate the effects of lower tidal volume ventilation, and other aspects of critical illness and ICU care, on the long-term clinical outcomes of individuals with ALI/ARDS.
Key facts
- Study ID
- NCT00300248
- Run by
- Johns Hopkins University
- People needed
- 520
- Starts
- 2004-10-01
- Expected to finish
- 2012-10-01
- Last updated by the study team
- 2015-09-01
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Residing in the ICU
- Receiving mechanical ventilation
- Meets criteria for the diagnosis of ALI/ARDS, as defined by the American-European Consensus Conference
You may not qualify if…
- Received diagnosis of ALI/ARDS more than 96 hours prior to study entry
- Received more than five days of mechanical ventilation during the present hospitalization prior to study entry
- Pre-existing ALI/ARDS for more than 24 hours when transferred to the study ICU
- Pre-existing illness with a life expectancy of less than six months
- Any limitations in ICU care at study entry (e.g., no vasopressor)
- Previous lung resection
- Inability to speak or understand English
- No fixed address
Where it is running
- University of Maryland Medical Center — Baltimore, Maryland, United States
- Veterans Affairs Hospital — Baltimore, Maryland, United States
- Johns Hopkins Hospital — Baltimore, Maryland, United States
- Bayview Medical Center — Baltimore, Maryland, United States
Full record on ClinicalTrials.gov
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