A Study of Dasatinib in Patients With Chronic Myelogenous Leukemia Who Are Resistant or Intolerant of Imatinib Mesylate

Completed · Phase 2

Conditions studied: Leukemia, Myeloid, Chronic, Leukemia, Lymphocytic, Acute, L2

In brief

The purpose of this clinical research study is to provide dasatinib treatment to patients with advanced chronic myelogenous leukemia (CML) or Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ ALL) who no longer can tolerate treatment with imatinib. The safety of the treatment will also be studied.

Key facts

Study ID

NCT00298987

Run by

Bristol-Myers Squibb

People needed

400

Starts

2006-02-01

Expected to finish

2007-06-01

Last updated by the study team

2010-02-08

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of accelerated phase or blast phase CML or Ph+ ALL
• Intolerant or resistant to imatinib mesylate
• 18 years of age or older
• ECOG performance 0-2 (greater than 50% of time out of bed)
• Adequate liver and kidney function

You may not qualify if…

• Pregnant or breastfeeding females
• History of significant cardiac disease
• History of significant bleeding disorder (not CML)
• Prisoners

Where it is running

• Local Institution — Corona, California, United States
• Local Institution — Aurora, Colorado, United States
• Local Institution — Colorado Springs, Colorado, United States
• Local Institution — Waterford, Connecticut, United States
• Local Institution — Daytona Beach, Florida, United States
• Local Institution — Jupiter, Florida, United States
• Local Institution — Atlanta, Georgia, United States
• Local Institution — Lawrenceville, Georgia, United States
• Local Institution — Beach Grove, Indiana, United States
• Local Institution — Indianapolis, Indiana, United States
• Local Institution — Iowa City, Iowa, United States
• Local Institution — Kansas City, Kansas, United States
• Local Institution — Salina, Kansas, United States
• Local Institution — Lexington, Kentucky, United States
• Local Institution — Louisville, Kentucky, United States
• Local Institution — Boston, Massachusetts, United States
• Local Institution — Ann Arbor, Michigan, United States
• Local Institution — Detroit, Michigan, United States
• Local Institution — Santa Fe, New Mexico, United States
• Local Institution — New York, New York, United States
• Local Institution — Cincinnati, Ohio, United States
• Local Institution — Cleveland, Ohio, United States
• Local Institution — Lawton, Oklahoma, United States
• Local Institution — Tulsa, Oklahoma, United States
• Local Institution — Portland, Oregon, United States

Full record on ClinicalTrials.gov

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