ACTIVE: Advanced Cognitive Training for Independent and Vital Elderly

Completed · Phase 2/Phase 3

Conditions studied: Aging, Healthy

In brief

The purpose of the ACTIVE study was to test if cognitive training interventions could maintain functional independence in elders by improving basic mental abilities, with follow-up assessments through five years.

Key facts

Study ID: NCT00298558
Run by: Carelon Research
People needed: 2832
Starts: 1998-03-01
Expected to finish: 2010-12-01
Last updated by the study team: 2014-04-16

Who can join

Age: 65 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

Age 65 or older
Mini-Mental State Examination (MMSE) score 23 or greater
Vision scored greater than 20/50
Minimal dependence in hygiene, bathing, and dressing

You may not qualify if…

Significant decline in cognitive skills, physical abilities, or functional independence
Inability to complete study activities as evidenced by MMSE and vision scores lower than Inclusion Criteria requirement
Diagnosis of Alzheimer's disease
Stroke in previous 12 months
Cancer with limited life expectance
Current chemotherapy or radiation treatment
Communication problems
Planned move from study area
Scheduling conflicts that would preclude participation in study activities
Prior involvement in similar cognitive training studies

Where it is running

University of Alabama at Birmingham — Birmingham, Alabama, United States
Indiana University — Indianapolis, Indiana, United States
Johns Hopkins University — Baltimore, Maryland, United States
Johns Hopkins University — Cumberland, Maryland, United States
Hebrew Rehabilitation Center for the Aged — Boston, Massachusetts, United States
Wayne State University — Detroit, Michigan, United States
Pennsylvania State University — University Park, Pennsylvania, United States

Full record on ClinicalTrials.gov

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