Are Two Antidepressants a Good Initial Treatment for Depression?
Completed · Phase 4
Conditions studied: Major Depression, Dysthymia, Depression NOS
In brief
Relatively drug naive patients will receive two antidepressant medications as initial treatment.
Key facts
- Study ID
- NCT00296712
- Run by
- New York State Psychiatric Institute
- People needed
- 55
- Starts
- 2005-02-01
- Expected to finish
- 2006-07-01
- Last updated by the study team
- 2012-04-27
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Currently depressed (DSM-IV Major Depression, Dysthymia or Depression NOS)
- HAMD-D (21-Item) > 9
You may not qualify if…
- Prior ineffective adequate trial on either study medication ($ 4 weeks on either escitalopram >20 mg/d or bupropion >300 mg/d; >4 weeks on citalopram >40 mg/d)
- History suggesting increased risk for Seizures (e.g., prior Seizure as an adult, diagnosed Seizure Disorder, taking medication known to increase seizure risk, history of significant head trauma, history of Bulimia or Anorexia)
- History of intolerance to either study medication unless patient and M.D. agree side effect is probably manageable
- Alcohol and/or drug abuse/dependence during past year
- Major medical problems that are not well controlled (e.g., untreated hypertension or diabetes)
- Bipolar I, Bipolar II
- History of Psychosis, or current Psychosis
- Currently taking antidepressants or mood stabilizers, which is judged unwise to discontinue (occasional sleep medication or benzodiazepine for Anxiety is allowed)
- Not currently depressed (whether considered due to current treatment or not)
- Active suicidal risk (history of suicide attempts will be evaluated on a case by case basis)
- Pregnant or breast-feeding
- Premenopausal women not using known effective birth control
Where it is running
- Depression Evaluation Service - New York State Psychiatric Institute — New York, New York, United States
Full record on ClinicalTrials.gov
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