Gastric Motor Function Measurement in Dyspepsia and Normal Subjects
Completed · Not applicable
Conditions studied: Dyspepsia
In brief
This study is being done to measure the functions of the stomach after eating a meal and to develop a new method that will simultaneously measure both gastric emptying and the relaxation of the stomach after a meal using nuclear medicine testing. This would make the testing more convenient for patients and will also offer better understanding of these two gastric functions.
Key facts
- Study ID
- NCT00296582
- Run by
- Mayo Clinic
- People needed
- 30
- Starts
- 2006-01-01
- Expected to finish
- 2007-06-01
- Last updated by the study team
- 2011-05-23
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Dyspeptic Subjects:
- Recurrent episodes of upper abdominal pain or discomfort including early satiety, fullness, bloating, or nausea for at least 3 months in the prior year.
- A baseline impaired satiety test (maximum tolerated volume 25% of normal or 1000cc).
- No evidence on esophagogastroduodenoscopy of erosions, peptic ulcer, pyloric obstruction, esophagitis or malignancy in the prior 3 years.
- All Subjects:
- No history suggestive of small bowel obstruction.
You may not qualify if…
- No structural or metabolic diseases/conditions that affect the gastrointestinal system.
- Unable to stop medications 48 hours prior to the study that:
- Alter GI transit including laxatives, magnesium or aluminum-containing antacids, prokinetics, erythromycin, narcotics, anticholinergics, tricyclic antidepressants, SSRI and newer antidepressants.
- Analgesic drugs including opiates, NSAID, COX 2 inhibitors
- Systemic antifungal drugs
- Carbamazepine, glucocorticoids, phenobarbital, phenytoin, rifampin, but also grapefruit juice.
- Benzodiazepines NOTE: Low stable doses of thyroid replacement, estrogen replacement, low dose aspirin for cardioprotection and birth control pills or depot injections are permissible.
- Female subjects who are pregnant or breast feeding.
- Significant cardiovascular, respiratory, renal, hepatic, gastrointestinal, hematological, neurological, psychiatric, or other disease that interfere with the objectives of the study.
- Subjects who have participated in another clinical study within the past 30 days.
- Previous gastric or intestinal surgery (except appendectomy , cholecystectomy or hysterectomy).
Where it is running
- Mayo Clinic — Scottsdale, Arizona, United States
Full record on ClinicalTrials.gov
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