Bortezomib, Rituximab, Cyclophosphamide, and Prednisone in Treating Patients With Relapsed or Refractory Indolent Non-Hodgkin's Lymphoma
Completed · Phase 1/Phase 2
Conditions studied: Leukemia, Lymphoma
In brief
RATIONALE: Bortezomib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as cyclophosphamide and prednisone, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as rituximab, can block cancer growth in different ways. Some block the ability of cancer cells to grow and spread. Others find cancer cells and help kill them or carry cancer-killing substances to them. Giving bortezomib together with cyclophosphamide, prednisone, and rituximab may be an effective treatment for non-Hodgkin's lymphoma. PURPOSE: This randomized phase I/II trial is studying the side effects and best dose of bortezomib when given together with cyclophosphamide, prednisone, and rituximab and to see how well it works in treating patients with relapsed or refractory indolent B-cell non-Hodgkin's lymphoma.
Key facts
- Study ID
- NCT00295932
- Run by
- Memorial Sloan Kettering Cancer Center
- People needed
- 79
- Starts
- 2005-12-13
- Expected to finish
- 2018-03-11
- Last updated by the study team
- 2018-11-20
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Winship Cancer Institute of Emory University — Atlanta, Georgia, United States
- Memorial Sloan-Kettering at Basking Ridge — Basking Ridge, New Jersey, United States
- Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School — New Brunswick, New Jersey, United States
- Memorial Sloan-Kettering Cancer Center @ Suffolk — Commack, New York, United States
- Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center — New York, New York, United States
- Memorial Sloan-Kettering Cancer Center — New York, New York, United States
- Memorial Sloan-Kettering at Mercy Medical Center — Rockville Centre, New York, United States
- Memoral Sloan Kettering Cancer Center@Phelps — Sleepy Hollow, New York, United States
Full record on ClinicalTrials.gov
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