Zoledronate in Treating Bone Marrow Micrometastases in Women With Stage I, Stage II, or Stage III Breast Cancer

Completed · Phase 2

Conditions studied: Breast Cancer

In brief

RATIONALE: Zoledronate may delay or prevent bone marrow metastases in patients with breast cancer. PURPOSE: This phase II trial is studying how well zoledronate works in treating bone marrow micrometastases in women with stage I, stage II, or stage III breast cancer.

Key facts

Study ID

NCT00295867

Run by

University of California, San Francisco

People needed

45

Starts

2004-11-03

Expected to finish

2013-12-01

Last updated by the study team

2020-05-12

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Women > 18 years of age with histologically or cytologically confirmed stage I, II or III breast cancer.
• If adjuvant chemotherapy is recommended, it must be completed before study start.
• Bone marrow aspirate positive by IC/FC assay
• a. Definition of positive: > 4 MM/ml b. Timing of bone marrow aspiration to determine study eligibility: i. If patient is to receive either no adjuvant therapy or hormonal therapy alone, the aspiration may be performed at diagnosis as part of the large MM study at University of California, San Francisco, or following diagnosis if the patient received initial surgery elsewhere. This is also true for patients who have surgery following neoadjuvant therapy for breast cancer.
• ii. If the patient is to receive adjuvant chemotherapy, the aspiration will be performed at least three weeks after chemotherapy has been completed.
• Adequate renal function as defined by:
• a. Creatinine must be < upper limit of normal
• Normal liver function tests including total bilirubin, alkaline phosphatase, and aspartate aminotransferase (AST) / serum glutamic-oxaloacetic transaminase (SGOT)
• Ability to understand and sign informed consent.
• Concomitant hormonal therapy is allowed
• Concomitant radiation therapy is allowed
• Patients who have had surgery following neoadjuvant chemotherapy or hormonal therapy are eligible to participate in this trial

You may not qualify if…

• History of allergy to bisphosphonates. Acute phase reactions occur in up to 24% of patients and disappear with subsequent dosing. An acute phase reaction does not qualify as an allergic reaction.
• History of renal insufficiency. Renal insufficiency is defined by a serum creatinine greater than the upper limit of normal or a creatinine clearance < 50 mL/min due to any underlying cause.
• Karnofsky Performance status < 90%.
• Any significant medical condition that might interfere with treatment.
• Women participating in this study are not allowed to receive other bisphosphonate therapy during the study period, either oral or intravenous.
• Patients who are pregnant

Where it is running

• University of California, San Francisco — San Francisco, California, United States

Full record on ClinicalTrials.gov

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