Effects of Volume Guarantee With Pressure Supported vs. Synchronized Intermittent Mandatory Ventilation in VLBW Infants
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Conditions studied: Respiratory Distress Syndrome
In brief
Studies in preterm infants have shown that adding volume guarantee (VG) to synchronized modes of ventilation is not only feasible but also advantageous for providing more constant and desirable mechanical breath size. This ideally minimizes ventilator-induced lung injury due to barotrauma and volutrauma. To date, only one recent study has investigated the relative advantages of combining VG with different modes of synchronized mechanical ventilation in clinically stable, preterm infants that were mechanically ventilated at an average age of one month. We aim to further evaluate the effects of PSV+VG versus SIMV+VG ventilation in very low birth weight infants within the first three to five days of life. Our hypothesis is that in very low birth weight infants requiring mechanical ventilation in the first three to five days of life, PSV+VG will allow for more stable physiologic and ventilatory parameters compared to SIMV+VG. The primary endpoints are a reduction in respiratory rate and average mean airway pressure in the PSV+VG group compared to the SIMV+VG group.
Key facts
- Study ID
- NCT00295230
- Run by
- Children's Hospitals and Clinics of Minnesota
- People needed
- 16
- Starts
- 2006-02-01
- Expected to finish
- 2007-09-01
- Last updated by the study team
- 2007-11-07
Who can join
Age: 0 and older, up to 0. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Infants will be recruited based on the following criteria: weight ≤1500 grams and need for mechanical ventilation at 72 - 120 hours of age. Recruitment will continue until 16 patients have completed the study
You may not qualify if…
- Exclusion criteria include significant endotracheal tube leak (>30% leak does not allow for accurate measurement of ventilator data), use of narcotic drip medication, use of paralytic medication, use of inhaled nitric oxide, fraction of inspired oxygen (FiO2) >70% at the time of enrollment, or significant congenital defects of any organ system (e.g. cardiac, respiratory, CNS).
Where it is running
- Children's Hospitals and Clinics of Minnesota — Minneapolis, Minnesota, United States
Full record on ClinicalTrials.gov
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