X-Chromosome Inactivation Status and Premature Ovarian Failure

Completed

Conditions studied: Premature Ovarian Failure

In brief

Women who are affected with premature ovarian failure will exhibit skewed X-chromosome inactivation patterns compared to women with normal menstrual function (as defined by being pregnant), indicating a possible X-chromosome defect.

Key facts

Study ID

NCT00295087

Run by

University of Pittsburgh

People needed

13

Starts

2005-11-01

Expected to finish

2009-10-01

Last updated by the study team

2014-12-08

Who can join

Age: 20 and older, up to 40. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Women diagnosed with POF.
• A chromosomal analysis must have been performed to evaluate X-chromosomal abnormalities, and the results are known to be normal.

You may not qualify if…

• Patients who have a known etiology for their POF and/or an inability to obtain karyotype results for these patients or unknown X-chromosome abnormalities.

Where it is running

• Magee-Womens Hospital — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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